Higher Absorption and Lower Urinary Elimination of a New Magnesium Rice Complex Compared to Two Other Organic Forms of Magnesium: A Pilot Study in Rats

Magnesium (Mg) supplementation may be required when certain health problems or conditions such as Crohn’s disease or pregnancy cause Mg deficiency for which increasing dietary intake is insufficient. Mg supplements are available as inorganic or organic forms, which are absorbed differently. Although inorganic salts are particularly rich in elemental Mg, organic forms are generally considered to be more bioavailable. This pilot study compared the pharmacokinetics and bioavailability following acute absorption in rats of two organic Mg forms to a new Mg rice complex made from an inorganic, marine Mg oxide and amino acids from a rice protein hydrolysate. The Mg rice complex was well absorbed from the gastrointestinal tract providing a relatively stable serum Mg concentration for up to 12 hours. The 24-h AUC for Mg rice complex was similar to the other two preparations. Mg urinary elimination for Mg rice complex was significantly lower than Mg bisglycinate, although did not significantly differ from Mg glycerophosphate or vehicle. No difference in fecal elimination was observed. The results suggest that Mg rice complex is at least as bioavailable as the two other forms tested. Containing almost twice the amount of elemental Mg than the two other forms, exposure to elemental Mg from Mg rice complex would be approximately twice as high as either Mg bisglycinate or Mg glycerophosphate for the same dose of supplement ingested. Consuming a Mg formulation with a higher, bioavailable content of elemental Mg could be particularly useful for preventing and treating Mg deficiency associated with various health problems. *Corresponding author: Angèle Guilbot, PiLeJe, 37 Quai de Grenelle, 75015 Paris cedex 15, France, Tel: +33 153867033; E-mail: [email protected] Citation: Bangratz M, Guinobert I, Dubourdeaux M, Guilbot A (2016) Higher Absorption and Lower Urinary Elimination of a New Magnesium Rice Complex Compared to Two Other Organic Forms of Magnesium: A Pilot Study in Rats. Gavin J Food Nutrit Sci 2016: 23-27. Received: 23 May, 2016; Accepted: 06 June, 2016; Published: 20 June, 2016